THE ROLE OF THE CYP17A1 RS743572 PROMOTER POLYMORPHISM IN THE DEVELOPMENT OF POLYCYSTIC OVARY SYNDROME IN WOMEN OF REPRODUCTIVE AGE

Abstract

Ovarian hyperandrogenism is a major pathogenetic component of PCOS, a disorder characterized by the coexistence of ovulatory dysfunction, androgen excess, and metabolic disturbances. This phenotype is driven by impaired steroidogenesis in ovarian theca cells and reduced tissue sensitivity to insulin and steroid hormones, while the marked phenotypic heterogeneity of PCOS necessitates clarification of its molecular genetic basis, including variation in steroidogenic genes (Goodarzi et al., 2011; Rosenfield and Ehrmann, 2016).